Our son was colicky when he was a 4-5 months old. Gripe water didn't work, and we actually found research that puts gripe water in a negative light. We were breastfeeding and supplementing with formula, and he would spit up often and wake up in the middle of the night. We stopped formula feeding and introduced Evivo at the same time around 6-months, and he seemed to get better. He is now almost 10 months old and when he sees the syringe he gets very excited, grabs hold and sucks on it so hard I barely have to push the plunger. We ultimately found Evivo while attending a class on introducing solids and decided to try it. My wife's family all have autoimmune diseases and there is increasing research that connects gut bacteria to diseases like MS. We're hoping this probiotic will help preventatively, and look forward to additional research about Evivo regarding autoimmune disease.