I just started taking FlexoPlex last Friday. I only have been taking one tablet twice per day opposed to the suggested use of two twice per day as a precaution because of the cat's claw ingredient. The bottle or website does not indicate the amount of cat's claw that is in FlexoPlex. Any way, I have been in excruciating joint, muscle pain and other body inflammation because of Lupus SLE. Later that day I did notice that my pain was minimum and my joint swelling was subsiding. The next day by Saturday afternoon, I was pain free with much mobility and no crackling of any joints. The crackling actually stopped that Friday night. I am so thankful for this supplement, it has gotten me back to feeling some normality. Although, I will consult with my physicians concerning the cat's claw with my health. There are other information that I can write but do not want to mislead other Lupus patients. God bless you all and those scientists at FlexoPlex.