I had used RetinA in gel form through my 20's & 30's as I suffered cystic acne. It was very irradiating and caused more problems than it was worth, (menopause seems to taken care of this-about the only good thing it did for me!). So when I saw this in a cream form at a lesser percentage strength, I thought I'd give it a try now that lines, 'spots' and wrinkles are a bigger issue for me. Well.... can't say I've been too impressed. I didn't notice any changes or improvements to my skin, line, or spots. While it did not irradiate my skin, I actually had 2 breakouts that I haven't had in this form for years. That was very upsetting. Now, of course this may have been just how my skin reacted and this may be a God-send for someone else. But for me it won't be anything I probably use in the future.