My shipment came early in climate controlled packaging and it was still cold. Neuralli has exceeded all expectations 10 fold! I purchased this for an Autistic adult and their improvements in all areas- sleep regulation, sensory integration, motor planning, mood regulation and trauma symptoms have all improved in ways that never were possible with any medications or therapies. They've also managed to stabalize a restrictive eating disorder on this probiotic which has also never been possible. Highly recommend! Only wish it was covered by insurance and that we could afford it long term.