I noticed the effects from these probiotics within days, my sluggish digestion returned to normal and I had increased energy levels. Although I did have a few more aches and pains to begin with probably due to the detoxing effect, these reduced considerably after that. I also noticed that a bad taste I was getting disappeared, probably due to the detox effect. Where I am most impressed is how much my sleep has improved, it was taking me hours to get to sleep now it takes minutes so definitely recommend these for insomnia. Powerful probiotics, you can feel the difference with these.