I'm still in the process of testing how well it works but I do like that the sting after application is mild and shortlived compared to my prescribed Tacrolimus ointment I've been using for over a year (which I found out today causes irreversible kidney damage, skin cancer and more) I hate that since childhood the medicine I've been given for various ailments actually expedite my misery and death. I am happy to see a healthy alternative but my afflictions are widespread and 1oz of tacrolimus won't even last me a week. I am willing to pay for more as I've seen noticeable improvement after the 1st application, but It would be significantly better if there were options to purchase a larger supply; I would happily pay $500+ for a 10oz of tremotyx that will last a month or more than pay for a 1oz tube that will last me only a few days!