I am only on day 6 of the 10 day course. Kinda too early to give a good assessment. I am not experiencing positive or negative changes yet. I am sure it needs time. One thing I didn’t like is a difference in the product description online and what the instructions say. On the site it just says a 10 day course of treatment. on the package instructions it says 10 day treatment is a maintenance treatment. and at times taken two capsules twice daily is for healing. If I had known that when I ordered, I wouldhave ordered more than one box while I had the money. now I have to wait realizing one box may not work. but ask me again after the 10 days is over