The Adafruit MCP2221A breakout fulfils my expectations completely! I bought it to create an easy interface between a desktop PC running Microsoft Flight Simulator 2020. The goal of the project in which I am using the MCP2221A breakout is to receive, filter and display the track flown by aircraft in use in the flight simulator. Data from the flight simulator is sent via a COM port of a PC running MS Windows (10 or 11). The data is fed to the USB-C input of the MCP2221A breakout. The output of the MCP2221A breakout, through its StemmaQT/qwiic connector, is fed to the StemmaQT/qwiic input of a Pimoroni i75 hub controller (PIM 584). On the MCP2221A I had to make 2 wire connections to let the MCP2221A convert USB-UART-to-I2C: Pin TX to Pin SCL and Pin RX to pin SDA (see the images). I also connected an external LED with a series resistor of 330 ohm between the MCP2221A breakout 5V pin and the SCL pin. This I did to let the LED indicate when GPS data has arrived. In the i7 hub controller I have running a micropython script that handles the received data. I added an Adafruit ISO154x optical I2C isolator between the MCP2221A breakout and the i75 hub controller. This was just a simple connect in series of the optical isolator that has two StemmaQT/qwiic connectors. This project is now running satisfactory. See the three images added. ToDo: create a repository on Github about this project. Check at: www.github.com/PaulskPt.